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The HBsAg-specific BCR knock-in mouse was constructed to study the characteristics of B cells in chronic HBV infection. An atypical pre-plasma cell population was identified post therapeutic vaccination in chronic HBV carrier mice. Atypical pre-plasma cells display enhanced BCR signaling, ER stress and apoptosis-related gene expression. Combination therapy (antibody + vaccine) partially ...
Hepatitis E virus (HEV) is a frequently overlooked causative agent of acute hepatitis. Evaluating the long-term durability of hepatitis E vaccine efficacy holds crucial importance. This study was an extension to a randomised, double-blind, placebo-controlled, phase-3 clinical trial of the hepatitis E vaccine conducted in Dontai County, Jiangsu, China. Participants were re...
Nasopharyngeal cancer is closely related to EBV infection, and China is a high incidence area, accounting for about half of the world's new cases every year. Early symptoms of nasopharyngeal cancer are not typical enough, and about 80% of patients are already in the middle or late stage when they are diagnosed, with poor treatment effect, short survival time and low quality of life. Screening b...
